Xigduo XR 10/500mg

Xigduo XR Medicine Description

Drug Class:

• Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitor and Biguanide Combination

Categories:

• Antidiabetic Medication
• Type 2 Diabetes Management

Active Ingredient Name:

• Dapagliflozin (SGLT2 Inhibitor)
• Metformin (Biguanide)

Popular and Other Names:

• Xigduo XR
• Extended-Release Dapagliflozin/Metformin Combination
• SGLT2 Inhibitor & Metformin Combo Tablets
• Dapagliflozin with Metformin XR

Mode of Action:

Xigduo XR combines two powerful mechanisms to control blood glucose in individuals with Type 2 diabetes:

• Dapagliflozin (SGLT2 Inhibitor): It blocks the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and promoting glucose excretion through urine. This lowers blood sugar levels and can aid in weight management.

• Metformin (Biguanide): It decreases glucose production in the liver and enhances the body’s sensitivity to insulin, which allows for better glucose utilization in cells.

This combination provides comprehensive control of blood sugar levels by targeting glucose production and excretion, making it a key therapy for managing Type 2 diabetes.

How to Use Xigduo XR:

• Form: Extended-release oral tablet.
• Administration: Take once daily in the morning with food to reduce the risk of gastrointestinal side effects. Swallow the tablet whole; do not crush, chew, or break it.
• Timing: Take the medication consistently at the same time every day for best results.

Recommended Dosage:

• Initial Dose: Typically, a dose of 5 mg Dapagliflozin/500 mg Metformin XR is prescribed once daily.
• Maintenance Dose: Depending on blood glucose levels and tolerability, the dose may be adjusted to a maximum of 10 mg Dapagliflozin/2000 mg Metformin XR per day.
• Adjustment: The dosage can be modified by a healthcare provider based on individual needs and kidney function.

Directions:

1. Take with Food: Always take Xigduo XR with meals to reduce the risk of stomach upset and improve absorption.
2. Hydration: Ensure adequate fluid intake, as the medication promotes glucose excretion, which can lead to dehydration.
3. Do Not Skip Doses: Maintain a consistent daily routine to effectively manage blood glucose levels.
4. Monitor Blood Sugar: Regularly monitor blood glucose to ensure optimal control.

Cautions:

1. Kidney Function: Xigduo XR is not recommended for patients with severe kidney impairment. Regular monitoring of kidney function is required.
2. Lactic Acidosis Risk: Metformin carries a risk of lactic acidosis, a rare but serious condition. Seek immediate medical attention if you experience symptoms like muscle pain, difficulty breathing, or stomach pain.
3. Dehydration and UTIs: Dapagliflozin increases urination, leading to a higher risk of dehydration and urinary tract infections (UTIs). Drink plenty of water and monitor for symptoms like painful urination.
4. Hypoglycemia: Though Xigduo XR itself does not cause hypoglycemia, combining it with insulin or other antidiabetic medications may increase the risk. Monitor blood glucose regularly.

Managing Side Effects:

1. Common Side Effects:

   • Nausea
   • Diarrhea
   • Increased urination
   • Thirst

   Management:
   Take the medication with food to reduce gastrointestinal symptoms. Stay hydrated to combat increased urination and thirst.

2. Serious Side Effects:

   • Lactic Acidosis: A rare but serious side effect of Metformin. Symptoms include muscle pain, difficulty breathing, and abdominal pain.
   • Ketoacidosis: Dapagliflozin can lead to ketoacidosis (high levels of ketones in the blood), even with normal blood sugar levels. Seek immediate medical help if you experience nausea, vomiting, abdominal pain, and confusion.

   Action:
   Discontinue use and consult your doctor if serious side effects occur.

Guidelines:

1. Healthy Lifestyle: Xigduo XR works best when combined with a healthy diet and regular exercise. Speak with your healthcare provider for personalized dietary recommendations.
2. Routine Monitoring: Regular blood sugar monitoring, along with kidney and liver function tests, is necessary to ensure safe and effective use of Xigduo XR.
3. Alcohol Consumption: Limit alcohol intake, as it can increase the risk of lactic acidosis with Metformin.
4. Pregnancy and Breastfeeding: Avoid Xigduo XR if pregnant or breastfeeding. Consult your doctor for alternatives if planning to conceive.

Frequently Asked Questions (FAQs):

1. What is Xigduo XR used for?
   Xigduo XR is used to manage blood sugar levels in adults with Type 2 diabetes, helping to lower the risk of cardiovascular events.

2. Can Xigduo XR help with weight loss?
   Yes, Dapagliflozin in Xigduo XR can promote mild weight loss by increasing glucose excretion through urine.

3. Can I take Xigduo XR with other diabetes medications?
   Xigduo XR can be combined with other antidiabetic medications, but it may increase the risk of hypoglycemia. Speak with your doctor for dosage adjustments.

4. What should I do if I miss a dose of Xigduo XR?
   Take the missed dose as soon as you remember, but skip it if it’s close to your next dose. Do not take extra medicine to make up for a missed dose.

5. Are there any foods I should avoid while taking Xigduo XR?
   While no specific foods need to be avoided, maintaining a balanced diet and following your healthcare provider’s recommendations will enhance the effectiveness of Xigduo XR.

6. Does Xigduo XR cause dehydration?
   Yes, Dapagliflozin in Xigduo XR can increase urination, leading to dehydration. Drink plenty of water to stay hydrated.

Quick Links:

• Xigduo XR for Type 2 Diabetes Management
  Learn more about how Xigduo XR helps control blood sugar levels in Type 2 diabetes.

• Xigduo XR Dosage Guide
  Detailed dosage recommendations and adjustments for Xigduo XR.

• Managing Side Effects of Xigduo XR
  Practical tips for managing common and serious side effects associated with Xigduo XR.

• Cautions for Taking Xigduo XR
  Essential cautions and precautions to consider before taking Xigduo XR, including kidney and liver health.