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About Product
Darzalex (Daratumumab) 100mg Injection
Darzalex (Daratumumab) 100mg Injection
Darzalex, containing the active ingredient Daratumumab, is a monoclonal antibody designed to target and eliminate cancerous cells in patients with multiple myeloma, a type of blood cancer. This innovative therapy works by binding to the CD38 protein found on the surface of myeloma cells, leading to their destruction through various immune-mediated mechanisms.
Drug Class and Categories: Darzalex falls under the class of monoclonal antibodies and is categorized as an antineoplastic agent. It is used primarily in the field of oncology for treating multiple myeloma.
Active Ingredient and Other Names:
Active Ingredient: Daratumumab
Popular and Other Names: Darzalex (brand name)
Mode of Action: Darzalex (daratumumab) is a monoclonal antibody that targets CD38, a protein highly expressed on the surface of multiple myeloma cells. By binding to CD38, Darzalex induces direct killing of these cancer cells through multiple mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and apoptosis.
How to Use It:
Administration: Darzalex is administered via intravenous infusion in a clinical setting.
Usage: Infusions are typically administered over a period of several hours, depending on the treatment regimen and patient tolerance.
Recommended Dosage:
Initial Treatment: 16 mg/kg of body weight administered weekly for the first 8 weeks, followed by every 2 weeks for 16 weeks, and then every 4 weeks.
Maintenance Therapy: Continue with 16 mg/kg every 4 weeks, as determined by the treating physician and patient response.
Directions:
Infusion Protocol: Administer Darzalex as an intravenous infusion over a period of 1 to 4 hours, depending on the patient's tolerance and response to the drug.
Preparation: Follow manufacturer guidelines for preparation and dilution. Ensure all procedures are sterile.
Cautions:
Pregnancy and Breastfeeding: Use Darzalex with caution if pregnant or breastfeeding. Discuss potential risks and benefits with your healthcare provider.
Pre-existing Conditions: Inform your healthcare provider of any pre-existing conditions, such as infections or liver problems, as these may affect treatment.
Infusion Reactions: Monitor for infusion-related reactions, which may include fever, chills, or difficulty breathing.
Manage Side Effects:
Common Side Effects: Fatigue, nausea, anemia, and infusion reactions such as fever and chills.
Severe Side Effects: Monitor for severe allergic reactions, infections, or low blood cell counts. Seek immediate medical attention if experiencing severe symptoms.
Guidelines:
Storage: Store Darzalex in the refrigerator (2°C to 8°C). Do not freeze. Protect from light.
Missed Dose: If a dose is missed, contact your healthcare provider to reschedule as soon as possible.
Overdose: In case of overdose, manage symptoms and monitor closely. Consult medical professionals for further action.
Frequently Asked Questions (FAQs):
What is Darzalex used for? Darzalex is used to treat multiple myeloma, a type of cancer that affects plasma cells in the bone marrow.
How is Darzalex administered? Darzalex is administered as an intravenous infusion in a clinical setting, typically every week for the initial treatment phase.
What are the common side effects of Darzalex? Common side effects include fatigue, nausea, anemia, and infusion-related reactions such as fever and chills.
What should I do if I miss a dose of Darzalex? Contact your healthcare provider to reschedule the missed infusion as soon as possible to stay on track with your treatment plan.
Are there any special precautions while using Darzalex? Yes, monitor for infusion-related reactions and report any severe symptoms or pre-existing conditions to your healthcare provider.
Can Darzalex be used in combination with other treatments? Yes, Darzalex is often used in combination with other drugs for enhanced effectiveness, depending on the treatment plan prescribed by your oncologist.
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Prescription Required Why?
India
