Lasmiditan (Reyvow) – Complete Product Guide for Waldrugmart Online Pharmacy

What is Lasmiditan (Reyvow)?

Lasmiditan, marketed under the brand name Reyvow, is a prescription medication used for the acute treatment of migraine with or without aura in adults. Unlike traditional migraine therapies such as triptans, Lasmiditan is the first in a new class of serotonin receptor agonists known as “ditans”. It is approved by the U.S. FDA and has shown high efficacy in clinical trials for patients with contraindications to vasoconstrictive drugs.

What is the active ingredient in Reyvow?

• Active Ingredient: Lasmiditan Hemisuccinate

• Brand Name: Reyvow

• Common Name: Lasmiditan

• Drug Class: Selective serotonin 5-HT1F receptor agonist (Ditans)

• DEA Schedule: Schedule V (low potential for abuse)

What is the mode of action of Lasmiditan?

Lasmiditan selectively binds to 5-HT1F serotonin receptors in the central nervous system. By inhibiting trigeminal nerve activity and neurotransmitter release, it interrupts migraine pathways without causing vasoconstriction, making it safer for patients with cardiovascular issues.

Key advantage: Unlike triptans, Lasmiditan does not act on blood vessels, making it suitable for individuals with a history of heart disease, stroke, or peripheral vascular disorders.

Clinical reference: Prescribing Information, FDA

What are the approved uses of Reyvow?

• Acute treatment of migraine attacks in adults

• With or without aura

• Not indicated for migraine prevention

What is the recommended dosage of Lasmiditan (Reyvow)?

• Starting dose: 50 mg, 100 mg, or 200 mg orally, once per migraine episode

• Maximum dose: One dose per 24-hour period

• Administration: With or without food

• Note: Patients should not drive or operate heavy machinery for at least 8 hours after a dose due to potential drowsiness and cognitive impairment.

Tablet strengths available:

• 50 mg

• 100 mg

• 200 mg

Who should not take Lasmiditan?

Lasmiditan is contraindicated in:

• Pediatric patients (under 18 years)

• People with hypersensitivity to Lasmiditan or excipients

• Patients planning to drive or use machinery within 8 hours of dosing

What are the most common side effects of Lasmiditan?

Based on clinical trials (SAMURAI and SPARTAN studies), common adverse effects include:

• Dizziness

• Fatigue

• Paresthesia (tingling sensation)

• Nausea

• Sedation

Less common but serious side effects:

• Driving impairment

• Serotonin syndrome (especially when taken with SSRIs/SNRIs)

• Hypersensitivity reactions

Source: FDA Label – Reyvow

Is Lasmiditan associated with drug interactions?

Yes. Caution is required with the following:

What precautions should be taken with Lasmiditan?

• Driving restriction: Patients must not drive or operate machinery for 8 hours after dosing.

• Pregnancy: Use only if benefits outweigh potential fetal risks (Category C).

• Breastfeeding: Unknown if Lasmiditan is excreted in breast milk.

• Medication Overuse Headache: Repeated use may lead to worsening headaches.

How effective is Lasmiditan in treating migraines?

Clinical trials have shown that:

• 32% of patients were pain-free at 2 hours with 200 mg

• Effective in patients with poor response to triptans

• More suitable for cardiac-compromised patients due to lack of vasoconstrictive activity

Reference: Kuca B, Silberstein SD, Wietecha L, et al. Evaluation of Lasmiditan for Acute Treatment of Migraine: Results from Two Phase 3 Randomized Studies. Lancet Neurol. 2019;18(11):1123-1132

Is Lasmiditan safe during pregnancy or breastfeeding?

• Pregnancy: No well-controlled studies; use only when clearly needed

• Breastfeeding: Exercise caution; insufficient data on excretion in human milk

Can Lasmiditan be used with other migraine medications?

• Not recommended with other 5-HT receptor agonists (e.g., triptans) within 24 hours.

• Avoid combining with SSRIs/SNRIs, MAO inhibitors, and other serotonergic agents without medical advice.

What makes Lasmiditan different from Triptans like Sumatriptan?

Frequently Asked Questions (FAQs)

Q1: Can Lasmiditan be used for chronic migraine?
A: No. It is only approved for acute treatment of individual migraine attacks, not for chronic or preventive therapy.

Q2: How fast does Reyvow work?
A: Onset of relief starts within 1 to 2 hours post-dose. Peak plasma levels are usually achieved in 1.5 hours.

Q3: Is Reyvow available over-the-counter?
A: No. It is a prescription-only medication due to its controlled status and potential side effects.

Q4: Can Lasmiditan be taken daily?
A: No. It should only be used as needed for acute migraine episodes, not more than one dose in 24 hours.

Buy Lasmiditan (Reyvow) Online – Waldrugmart Trusted Pharmacy

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