What is Supatret C Gel?
A fixed‐dose topical formulation combining clindamycin phosphate 1% and tretinoin 0.04% in an aqueous gel base, indicated for mild to moderate acne vulgaris on the face, chest, or back in patients 12 years and older.
What are the active ingredients?
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Clindamycin phosphate 1% w/w: a lincosamide antibiotic that inhibits bacterial protein synthesis, reducing Cutibacterium acnes proliferation.
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Tretinoin 0.04% w/w: a vitamin A derivative (retinoid) that accelerates keratinocyte turnover, preventing follicular plugging and promoting comedone extrusion.
Other popular and common names
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Generic: clindamycin–tretinoin gel.
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Comparable brands: Clin‑RA®, Velac®, Ziana®, Duac‑T®—each varying slightly in concentration or vehicle.
How does Supatret C Gel work?
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Antimicrobial: Clindamycin disrupts early stages of bacterial protein synthesis, targeting acne‑causing bacteria.
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Comedolytic: Tretinoin normalizes skin cell shedding, prevents new comedone formation, and aids in clearing existing lesions.
How should it be used?
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Cleanse skin with a mild, non‑medicated cleanser.
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Pat the area dry and wait 20–30 minutes.
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Apply a thin, even layer of gel once daily in the evening to affected areas.
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Avoid contact with eyes, lips, and mucous membranes.
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Use broad‑spectrum sunscreen (SPF 30+) and protective clothing during the day.
What is the recommended dosage and duration?
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Dosage: Once‑daily evening application; a 15 g tube typically covers the face, chest, or back.
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Duration: 8–12 weeks for full effect; may be extended up to 24 weeks per physician assessment.
What are the possible side effects?
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Common: redness, dryness, peeling, burning, stinging, itching, increased sensitivity to sunlight.
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Uncommon: excessive scaling, hyperpigmentation, sunburn susceptibility, faint rash.
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Rare: systemic reactions such as headache or gastrointestinal upset if overused.
What warnings and precautions apply?
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Pregnancy/Lactation: Contraindicated in pregnancy; category C. Breastfeeding is not recommended without physician approval.
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Age: Safety in children under 12 years not established; use with caution in elderly patients.
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Photosensitivity: Tretinoin increases sun sensitivity—strict sun protection is essential.
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Concomitant Topicals: Avoid simultaneous use of other irritating agents (e.g., benzoyl peroxide, salicylic acid, chemical peels).
What drug interactions should be considered?
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Topical: Amplified local irritation with other peeling or drying agents.
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Systemic: Minimal systemic absorption, but clindamycin may potentiate neuromuscular blockers and alter gut flora–mediated vitamin K synthesis, potentially affecting warfarin therapy.
What clinical evidence supports its use?
Randomized, double‑blind Phase III studies have demonstrated that clindamycin/tretinoin gel produces significantly greater reductions in both inflammatory and non‑inflammatory acne lesions over 12 weeks compared to monotherapy, with a tolerability profile similar to each component used alone.
Where to buy
Purchase Supatret C Gel from Waldrugmart Online Pharmacy:
https://waldrugmart.com/products/supatret-c-gel
Frequently Asked Questions
Q: How soon will I see results?
Most users report noticeable improvement by 6–8 weeks, with optimal outcomes at around 12 weeks. Continued use can further reduce residual marks and comedones.
Q: Can I combine Supatret C Gel with other acne treatments?
Combining with over‑the‑counter exfoliants or retinoids is not advised due to increased irritation; always consult a dermatologist before adding other therapies.
Q: What sun protection measures are necessary?
Daily application of a broad‑spectrum SPF 30+ sunscreen and wearing protective clothing are essential to prevent sunburn and photo‑damage.
Q: Is Supatret C Gel suitable for other skin conditions?
Its safety and efficacy outside acne vulgaris remain unestablished; patients with rosacea, perioral dermatitis, or eczema should seek alternative treatments.
Q: What if I experience irritation?
For mild irritation, reduce frequency to every other night or pause for 1–2 days. Discontinue and consult a physician if severe reactions occur.
Q: Is it safe during breastfeeding?
Use during lactation is not well studied; discuss risks and benefits with your healthcare provider.
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