Kerendia is a prescription medication used to reduce the risk of kidney damage and cardiovascular problems in patients with chronic kidney disease (CKD) associated with type 2 diabetes. It works by blocking the action of aldosterone, a hormone that plays a key role in regulating blood pressure and fluid balance. By reducing the effects of aldosterone, Kerendia helps protect the kidneys and heart from further damage.

Drug Class:

• Drug Class: Nonsteroidal Mineralocorticoid Receptor Antagonist (MRA)
• Categories: Antihypertensive, Nephroprotective Agent, Cardiovascular Risk Reduction

Active Ingredient Name:

• Active Ingredient: Finerenone

Popular and Other Names:

• Brand Name: Kerendia
• Generic Name: Finerenone
• Other Names: Finerenone Tablets

Mode of Action:

Kerendia contains Finerenone, a nonsteroidal mineralocorticoid receptor antagonist (MRA). It works by blocking the effects of aldosterone, a hormone that causes sodium and fluid retention, leading to high blood pressure and increased strain on the kidneys and heart. By inhibiting aldosterone’s action, Finerenone helps:

1. Reduce Kidney Inflammation and Fibrosis: This protects the kidneys from damage in patients with CKD.
2. Lower Blood Pressure: Reduces fluid retention and blood pressure, lowering the risk of cardiovascular problems.
3. Protect the Heart: Reduces the risk of heart failure and cardiovascular death in patients with CKD and type 2 diabetes.

How to Use It:

Kerendia is an oral medication and should be taken once daily as directed by a healthcare provider. It is typically used as part of a comprehensive treatment plan for CKD in type 2 diabetes, along with other medications such as antihypertensives and diabetes medications.

Recommended Dosage:

• Starting Dose: 10 mg or 20 mg once daily, depending on the patient’s kidney function and potassium levels.
• Maintenance Dose: Adjust the dose to 20 mg once daily based on serum potassium levels and kidney function.
• Monitoring: Regular monitoring of potassium levels and kidney function is necessary to determine the appropriate dose.

Directions:

1. Take Kerendia once daily, with or without food.
2. Swallow the tablet whole with water; do not crush or chew it.
3. If you miss a dose, take it as soon as you remember. If it’s close to the time of the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.

Cautions:

• Hyperkalemia (High Potassium Levels): Kerendia can increase potassium levels, which may lead to serious health issues. Potassium levels should be monitored regularly during treatment, especially in patients with impaired kidney function.
• Severe Liver Impairment: Use with caution in patients with severe liver disease, as Finerenone metabolism may be impaired.
• Pregnancy and Breastfeeding: Consult your healthcare provider before using Kerendia if you are pregnant or breastfeeding. It is not recommended for use during pregnancy unless absolutely necessary.
• Drug Interactions: Avoid combining Kerendia with other potassium-sparing drugs (such as spironolactone) and NSAIDs, as this may increase the risk of hyperkalemia. Always inform your healthcare provider about all medications and supplements you are taking.

Managing Side Effects:

• Common Side Effects: Hyperkalemia, low blood pressure (hypotension), dizziness, fatigue, and dehydration.
• Serious Side Effects: Signs of dangerously high potassium levels, such as muscle weakness, irregular heartbeat, or chest pain. Seek immediate medical attention if these symptoms occur.
• Management Tips: Maintain adequate hydration and follow a low-potassium diet if recommended by your healthcare provider. For serious symptoms, discontinue the medication and seek emergency medical care.

Guidelines:

1. Regular Monitoring: Regular blood tests are necessary to monitor potassium levels and kidney function while on Kerendia.
2. Adherence to Diet: Follow any dietary recommendations, especially a low-potassium diet, to avoid complications.
3. Do Not Stop Without Consultation: Do not stop taking Kerendia without consulting your healthcare provider, as this may lead to worsening kidney or heart conditions.
4. Avoid Potassium Supplements: Unless recommended by a doctor, avoid potassium supplements or potassium-rich foods, as these can increase the risk of hyperkalemia.

Frequently Asked Questions (FAQs)

1. What is Kerendia used for?

   • Kerendia is used to reduce the risk of kidney damage and cardiovascular complications in patients with chronic kidney disease (CKD) associated with type 2 diabetes.

2. How does Kerendia protect the kidneys?

   • Kerendia works by blocking the action of aldosterone, a hormone that can cause inflammation and fibrosis in the kidneys. By reducing aldosterone’s effects, it helps protect the kidneys from further damage.

3. Can Kerendia lower blood pressure?

   • Yes, Kerendia helps reduce blood pressure by decreasing fluid retention and improving kidney function.

4. What are the most common side effects of Kerendia?

   • The most common side effects include hyperkalemia (high potassium levels), low blood pressure, and dizziness.

5. How is hyperkalemia managed while taking Kerendia?

   • Regular monitoring of potassium levels is required, and dietary modifications (such as a low-potassium diet) may be recommended to manage hyperkalemia.

6. Can I take Kerendia with other medications?

   • It is important to inform your healthcare provider about all medications you are taking. Kerendia should not be used with other potassium-sparing medications, as this increases the risk of hyperkalemia.

7. Is Kerendia safe during pregnancy?

   • Kerendia is not typically recommended during pregnancy. Always consult your healthcare provider if you are pregnant or planning to become pregnant while on Kerendia.

8. How often do I need blood tests while taking Kerendia?

   • Blood tests should be done regularly, especially during the first months of treatment, to monitor potassium levels and kidney function.

9. Can I stop taking Kerendia if I feel better?

   • No, do not stop taking Kerendia without consulting your healthcare provider, even if you feel better. Stopping the medication may worsen your condition.