Retevmo is a prescription medication containing the active ingredient Selpercatinib, a targeted cancer therapy used to treat certain types of cancers driven by RET gene mutations or fusions. It is specifically indicated for the treatment of patients with non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and other types of thyroid cancer that have RET alterations. Retevmo works by inhibiting the activity of the RET protein, which plays a crucial role in the growth and survival of cancer cells.

Drug Class:

• Drug Class: Kinase Inhibitor, Targeted Therapy
• Categories: Cancer Treatment, Precision Medicine, Targeted Cancer Therapy

Active Ingredient Name:

• Active Ingredient: Selpercatinib

Popular and Other Names:

• Brand Name: Retevmo
• Generic Name: Selpercatinib
• Other Names: RET Inhibitor, Selpercatinib Capsules

Mode of Action:

Retevmo targets and inhibits the activity of the RET (Rearranged during Transfection) kinase, a protein that is abnormally activated in cancers with RET gene mutations or fusions. By blocking the RET protein’s activity, Retevmo helps:

1. Inhibit Tumor Growth: Prevents cancer cells from proliferating, thereby reducing tumor size and slowing disease progression.

2. Induce Cancer Cell Death: Triggers mechanisms within the cancer cells that lead to apoptosis (programmed cell death), effectively eliminating some cancer cells.

3. Minimize Metastasis: Helps reduce the spread of cancer to other parts of the body, improving patient outcomes.

This targeted approach ensures that the therapy is more specific to cancer cells with RET alterations, while having a lesser effect on normal, healthy cells.

How to Use It:

Retevmo is taken orally in capsule form, typically under the supervision of an oncologist. It is important to follow the prescribed dosing schedule for optimal results.

Recommended Dosage:

• Adults and Pediatric Patients (≥12 Years):
  • Body Weight ≥50 kg: 160 mg twice daily.
  • Body Weight <50 kg: 120 mg twice daily.
• Duration: Treatment continues until disease progression or unacceptable toxicity occurs. Always follow your oncologist's recommendations for dosing and duration.

Directions:

1. Take with or without Food: Swallow the capsules whole with water. Do not crush, chew, or open the capsules.
2. Consistent Timing: Take the medication at the same time each day to maintain stable blood levels.
3. Missed Dose: If a dose is missed by more than 6 hours, skip the missed dose and resume the regular schedule. Do not take an extra dose to make up for the missed one.

Cautions:

• Liver Monitoring: Retevmo may cause liver toxicity. Regular monitoring of liver function tests is recommended.
• Blood Pressure Monitoring: Patients should have their blood pressure monitored regularly, as hypertension may occur.
• Avoid in Pregnancy: Retevmo can harm an unborn baby. It should not be used during pregnancy, and effective contraception should be used during treatment and for at least 1 week after the last dose.
• Drug Interactions: Avoid taking Retevmo with certain medications that can affect liver enzymes, as they may alter the effectiveness of the treatment. Inform your doctor about all medications you are taking.

Managing Side Effects:

• Common Side Effects: Include dry mouth, diarrhea, high blood pressure, fatigue, nausea, and constipation.
• Serious Side Effects: May include liver problems, severe hypertension, bleeding, allergic reactions, and heart rhythm abnormalities (QT prolongation). If you experience any serious symptoms, contact your healthcare provider immediately.
• Management Tips: Stay hydrated and eat small, frequent meals to manage nausea. Monitor blood pressure regularly and follow dietary recommendations if advised by your healthcare team.

Guidelines:

1. Regular Monitoring: Follow your healthcare provider’s instructions for regular monitoring of blood tests, liver function, and blood pressure.
2. Report Symptoms: Inform your healthcare provider of any new or worsening symptoms, including unexplained bleeding, chest pain, or swelling.
3. Use Effective Birth Control: Use contraception during treatment and for 1 week after the last dose if you are of childbearing potential.

Frequently Asked Questions (FAQs)

1. What is Retevmo used for?

   • Retevmo is used to treat certain types of cancers with RET gene mutations or fusions, including non-small cell lung cancer, medullary thyroid cancer, and other thyroid cancers.

2. How does Retevmo work?

   • Retevmo inhibits the RET protein's activity, which is involved in cancer cell growth and survival. By blocking this protein, it helps reduce tumor growth and spread.

3. Can Retevmo be used as a first-line treatment?

   • Yes, Retevmo can be used as a first-line treatment for patients with RET-positive cancers.

4. How long should I take Retevmo?

   • Treatment with Retevmo typically continues until the cancer progresses or significant side effects occur. Your oncologist will determine the duration based on your response.

5. What should I do if I miss a dose of Retevmo?

   • If you miss a dose by more than 6 hours, skip it and resume your regular dosing schedule. Do not take a double dose to make up for the missed one.

6. Are there any dietary restrictions while taking Retevmo?

   • There are no specific dietary restrictions, but avoid grapefruit and grapefruit juice, as they may interact with the medication.

7. Can I take Retevmo if I’m pregnant?

   • No, Retevmo can harm an unborn baby. It should not be used during pregnancy, and effective contraception should be used during treatment.

8. Does Retevmo cause high blood pressure?

   • Yes, high blood pressure is a common side effect. Regular monitoring and management by your healthcare provider are recommended.

Quick Links:

• Retevmo Product Information
• RET Inhibitors in Cancer Treatment
• Managing Side Effects of Targeted Cancer Therapies
• Understanding RET Gene Mutations
• Retevmo Dosage Guidelines